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Article

Essential regions of the tRNA primer required for HIV-1 infectivity.

Nucleic acids research - 1 Dec 2000

Yu Q, Morrow C D

Abstract excerpt

Human immunodeficiency virus (HIV), like all retroviruses, requires a cellular tRNA as a primer for initiation of reverse transcription. In a previous study, we demonstrated that an HIV-1 with a primer binding site complementary to yeast tRNA(Phe) (psHIV-Phe) was not infectious unless yeast tRNA(Phe) was supplied in trans. This unique in vivo complementation system has now been used to define the elements of the...

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Identifiers

PMID: 11095691
DOI: 10.1093/nar/28.23.4783
PMCID: PMC115161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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