Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of sequences downstream of the primer binding site that are important for efficient replication of human immunodeficiency virus type 1.

Journal of virology - 1 Aug 1997

Li X, Liang C, Quan Y, Chandok R, Laughrea M, Parniak M A, Kleiman L, Wainberg M A

Abstract excerpt

Reverse transcription of retroviruses is initiated from an 18-nucleotide (nt) primer binding site (PBS), located within the 5' region of viral genomic RNA, to which the host cell-derived tRNA primer is annealed and also involves viral genomic sequences outside the PBS. We constructed proviral DNA clones of human immunodeficiency virus (HIV) that had selective deletions of either a 7-nt segment found immediately...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to DNA, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to RNA, Viral

Share to Viral Proteins

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 9223491
DOI: 10.1128/JVI.71.8.6003-6010.1997
PMCID: PMC191857

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of sequences downstream of the primer binding site that are important for efficient replication of human immunodeficiency virus type 1.PMID 9223491Read ↗

Effects of alterations of primer-binding site sequences on human immunodeficiency virus type 1 replicationSemantic proximity Read ↗

Deletions in the tRNA(Lys) primer-binding site of human immunodeficiency virus type 1 identify essential regions for reverse transcriptionSemantic proximity Read ↗

Minimal sequence requirements of a functional human immunodeficiency virus type 1 primer binding site.Semantic proximity Read ↗

Mutations within the primer binding site of the human immunodeficiency virus type 1 define sequence requirements essential for reverse transcription.Semantic proximity Read ↗

Sequences in the 5' and 3' R elements of human immunodeficiency virus type 1 critical for efficient reverse transcription.Semantic proximity Read ↗

Efficient initiation of HIV-1 reverse transcription in vitro. Requirement for RNA sequences downstream of the primer binding site abrogated by nucleocapsid protein-dependent primer-template interactions.Semantic proximity Read ↗

Mutations in both the U5 region and the primer-binding site influence the selection of the tRNA used for the initiation of HIV-1 reverse transcription.Semantic proximity Read ↗

The tRNA primer activation signal in the human immunodeficiency virus type 1 genome is important for initiation and processive elongation of reverse transcription.Semantic proximity Read ↗

Spliced human immunodeficiency virus type 1 RNA is reverse transcribed into cDNA within infected cells.Semantic proximity Read ↗

Reduced replication of human immunodeficiency virus type 1 mutants that use reverse transcription primers other than the natural tRNA(3Lys).Semantic proximity Read ↗

Leader sequences downstream of the primer binding site are important for efficient replication of simian immunodeficiency virus.Semantic proximity Read ↗

Construction of a type 1 human immunodeficiency virus that maintains a primer binding site complementary to tRNA(His).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.