Identification of sequences downstream of the primer binding site that are important for efficient replication of human immunodeficiency virus type 1.

doi:10.1128/JVI.71.8.6003-6010.1997

Back to search

Article

Identification of sequences downstream of the primer binding site that are important for efficient replication of human immunodeficiency virus type 1.

Journal of virology - 1 Aug 1997

Li X, Liang C, Quan Y, Chandok R, Laughrea M, Parniak M A, Kleiman L, Wainberg M A

Abstract excerpt

Reverse transcription of retroviruses is initiated from an 18-nucleotide (nt) primer binding site (PBS), located within the 5' region of viral genomic RNA, to which the host cell-derived tRNA primer is annealed and also involves viral genomic sequences outside the PBS. We constructed proviral DNA...

Topics

Binding Sites
DNA, Viral
HIV-1
Humans
Mutation
RNA, Viral
Viral Proteins
Virus Replication

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.