Article
Wn mutation of c-kit receptor affects its post-translational processing and extracellular expression.
Oncogene - 1 Jan 1994
Koshimizu U, Tsujimura T, Isozaki K, Nomura S, Furitsu T, Kanakura Y, Kitamura Y, Nishimune Y
Abstract excerpt
The W locus of mice encodes the c-kit receptor tyrosine kinase. Recently, we characterized a novel mutant allele, Wn, and demonstrated that the c-kit protein synthesized in Wn/Wn cultured mast cells (CMC) was reduced in size and not expressed on their surface (Tsujimura et al., 1993). In this study, we further examined biochemical nature of the mutant form of c-kit protein, by using Wn/Wn CMC and 293T cells...
Topics
- Alleles
- Animals
- Cells, Cultured
- Mast Cells
- Mice
- Point Mutation
- Protein Conformation
- Protein Processing, Post-Translational
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-kit
- Receptor Protein-Tyrosine Kinases