Structure of the P1 helix from group I self-splicing introns.

doi:10.1006/jmbi.1995.0381

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Article

Structure of the P1 helix from group I self-splicing introns.

Journal of molecular biology - 14 Jul 1995

Allain F H, Varani G

Abstract excerpt

The upstream cleavage site of group I self-splicing introns is identified by an absolutely conserved U.G base-pair within a double helix. Mutant introns with a wobble C.A substitute are catalytically active, but all other combinations of nucleotides at these positions abolish splicing, suggesting...

Topics

Base Composition
Base Sequence
Introns
Magnetic Resonance Spectroscopy
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
RNA Splicing
RNA, Catalytic

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