Comparable impact of mutational and selective influences in shaping the expressed repertoire of peripheral IgM+/CD5- and IgM+/CD5+ B cells.

doi:10.1002/(SICI)1521-4141(199802)28:02<657::AID-IMMU657>3.0.CO;2-Z

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Article

Comparable impact of mutational and selective influences in shaping the expressed repertoire of peripheral IgM+/CD5- and IgM+/CD5+ B cells.

European journal of immunology - 1 Feb 1998

Dörner T, Brezinschek H P, Foster S J, Brezinschek R I, Farner N L, Lipsky P E

Abstract excerpt

Somatic hypermutation and subsequent selection play a significant role in shaping the peripheral B cell repertoire. This repertoire is composed of CD5+ (5%) and CD5- B cells (95%) which are known to traffic through different lymphoid compartments. Previous studies have shown that V(H) gene usage...

Topics

Adenine
Adult
B-Lymphocyte Subsets
CD5 Antigens
Codon
Cytosine
DNA Mutational Analysis
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Guanine
Humans
Immunoglobulin Heavy Chains
Immunoglobulin Joining Region
Immunoglobulin M
Immunoglobulin Variable Region

Source

Open in PubMed

Identifiers

PMID: 9521076
DOI: 10.1002/(SICI)1521-4141(199802)28:02<657::AID-IMMU657>3.0.CO;2-Z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9521076-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Male

Middle Aged

Molecular Sequence Data

Mutation