Article
Protective capacity of virus-specific T cell receptor-transduced CD8 T cells in vivo.
Journal of virology - 1 Oct 2012
Mueller Katja, von Mässenhausen Anne, Aichele Ulrike, Stärck Lilian, Leisegang Matthias, Uckert Wolfgang, Pircher Hanspeter
Abstract excerpt
The transfer of T cell receptor (TCR) genes by viral vectors represents a promising technique to generate antigen-specific T cells for adoptive immunotherapy. TCR-transduced T cells specific for infectious pathogens have been described, but their protective function in vivo has not yet been exami...
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