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Article

An ionizing radiation-sensitive mutant of CHO cells: irs-20. I. Isolation and initial characterization.

Radiation research - 1 Nov 1993

Stackhouse M A, Bedford J S

Abstract excerpt

We have isolated a stable mutant of CHO cells, designated irs-20, that is hypersensitive to ionizing radiation. The selection system was designed to select for mutants unable to proliferate at the low dose rate of 0.06 Gy per hour, a dose rate that has little influence on the effect of radiation on the cell cycle of wild-type cells during 1- to 2-week exposures. The irs-20 mutant cells irradiated continuously at...

Topics

Animals
Azacitidine
CHO Cells
Cell Cycle
Cell Separation
Cell Survival
Cricetinae
Cricetulus
Karyotyping
Mutation
Radiation Tolerance
Radiation, Ionizing

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PMID: 7504309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7504309-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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