Article
Cytogenetic characterization of the ionizing radiation-sensitive Chinese hamster mutant irs1.
Mutation research - 1 Mar 1991
Tucker J D, Jones N J, Allen N A, Minkler J L, Thompson L H, Carrano A V
Abstract excerpt
The X-ray-sensitive mutant V79 cell line irs1 was characterized with respect to chromosomal aberrations induced by 137Cs, mitomycin C (MMC), and decarbamoyl mitomycin C (DCMMC). To measure chromosome damage induced at different cell cycle stages, irs1 and the parental V79-4 cell lines were pulse-labeled with bromodeoxyuridine (BrdUrd) at the time of exposure and harvested at various intervals corresponding to...
Topics
- Alkylating Agents
- Animals
- Cell Cycle
- Chromosome Aberrations
- Cricetinae
- DNA
- DNA Repair
- Mitomycin
- Mitomycins
- Mutation
- Radiation Tolerance
- Radiation, Ionizing