Article
Nonsense suppressor and antisuppressor mutations at the 1409-1491 base pair in the decoding region of Escherichia coli 16S rRNA.
Nucleic acids research - 11 Nov 1995
Gregory S T, Dahlberg A E
Abstract excerpt
Using a genetic selection for suppressors of a UGA nonsense mutation in trpA, we have isolated a G to A transition mutation at position 1491 in the decoding region of 16S rRNA. This suppressor displayed no codon specificity, suppressing UGA, UAG and UAA nonsense mutations and +1 and -1 frameshift mutations in lacZ. Subsequent examination of a series of mutations at G1491 and its base-pairing partner C1409...
Topics
- Base Sequence
- Codon, Nonsense
- Escherichia coli
- Frameshift Mutation
- Genetic Code
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Protein Biosynthesis
- RNA, Bacterial
- RNA, Ribosomal, 16S