Article
Structural and functional accommodation of nucleotide variations at a conserved tRNA tertiary base pair.
RNA (New York, N.Y.) - 1 Oct 1995
Sterner T, Jansen M, Hou Y M
Abstract excerpt
The U8:A14 tertiary base pair of transfer RNAs (tRNAs) stabilizes the sharp turn from the acceptor stem to the dihydrouridine stem. This tertiary base pair is important for the overall L-shaped tRNA structure. Inspection of tRNA sequences shows that U8:A14 is highly conserved. However, variations of U8:A14 are found in natural sequences. This raises the question of whether all 16 permutations of U8:A14 can be...
Topics
- Bacterial Proteins
- Base Composition
- Base Sequence
- Conserved Sequence
- Escherichia coli
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- RNA, Transfer, Ala
- Ribonucleotides