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Article

Ribosomes containing the C1054-deletion mutation in E. coli 16S rRNA act as suppressors at all three nonsense codons.

Nucleic acids research - 11 Oct 1991

Prescott C, Krabben L, Nierhaus K

Abstract excerpt

It was established some time ago that the deletion of base C1054 in E. coli 16S rRNA specifically affects UGA-dependent termination of translation. Based on this observation, a model for the termination event was proposed in which the UGA nonsense codon on the mRNA base-pairs with a complementary motif in 'helix 34' of the 16S rRNA, thus potentially providing a recognition signal for the binding of the release...

Topics

Codon
Escherichia coli
Gene Expression
Mutation
Nucleic Acid Conformation
RNA, Ribosomal, 16S
Recombinant Fusion Proteins
Ribosomes
Suppression, Genetic
Transformation, Genetic
beta-Galactosidase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1923812
DOI: 10.1093/nar/19.19.5281
PMCID: PMC328888

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1923812-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Ribosomes containing the C1054-deletion mutation in E. coli 16S rRNA act as suppressors at all three nonsense codons.PMID 1923812Read ↗

The involvement of base 1054 in 16S rRNA for UGA stop codon dependent translational termination.Semantic proximity Read ↗

A rRNA-mRNA base pairing model for UGA-dependent termination.Semantic proximity Read ↗

Mutations in helix 34 of Escherichia coli 16 S ribosomal RNA have multiple effects on ribosome function and synthesis.Semantic proximity Read ↗

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A ribosomal ambiguity mutation in the 530 loop of E. coli 16S rRNA.Semantic proximity Read ↗

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An Alternative Role of RluD in the Fidelity of Translation Initiation in Escherichia coli.Semantic proximity Read ↗

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