Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interaction between the ribosomal subunits: 16S rRNA suppressors of the lethal DeltaA1916 mutation in the 23S rRNA of Escherichia coli.

Molecular genetics and genomics : MGG - 1 Sept 2007

O'connor Michael

Abstract excerpt

A1916 in 23S rRNA is located in one of the major intersubunit bridges of the 70S ribosome. Deletion of A1916 disrupts the intersubunit bridge B2a, promotes misreading of the genetic code and is lethal. In a genetic selection for suppressor mutations, two base substitutions in 16S rRNA were recovered that restored viability and also allowed expression of DeltaA1916-associated capreomycin resistance. These...

Topics

Capreomycin
Drug Resistance, Bacterial
Escherichia coli
Genes, Bacterial
Genes, Lethal
Macromolecular Substances
Models, Molecular
Mutation
RNA, Bacterial
RNA, Ribosomal, 16S
RNA, Ribosomal, 23S

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ribosomes

Suppression, Genetic

Source

Identifiers

PMID: 17564727
DOI: 10.1007/s00438-007-0252-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction between the ribosomal subunits: 16S rRNA suppressors of the lethal DeltaA1916 mutation in the 23S rRNA of Escherichia coli.PMID 17564727Read ↗

A functional relationship between helix 1 and the 900 tetraloop of 16S ribosomal RNA within the bacterial ribosome.Semantic proximity Read ↗

Analysis of the function of E. coli 23S rRNA helix-loop 69 by mutagenesis.Semantic proximity Read ↗

Selection for intragenic suppressors of lethal 23S rRNA mutations in Escherichia coli identifies residues important for ribosome assembly and function.Semantic proximity Read ↗

Mutations in the intersubunit bridge regions of 16S rRNA affect decoding and subunit-subunit interactions on the 70S ribosome.Semantic proximity Read ↗

Functional genetic selection of Helix 66 in Escherichia coli 23S rRNA identified the eukaryotic-binding sequence for ribosomal protein L2.Semantic proximity Read ↗

rRNA modifications in an intersubunit bridge of the ribosome strongly affect both ribosome biogenesis and activity.Semantic proximity Read ↗

An arc of unpaired "hinge bases" facilitates information exchange among functional centers of the ribosome.Semantic proximity Read ↗

A ribosomal ambiguity mutation in the 530 loop of E. coli 16S rRNA.Semantic proximity Read ↗

Nonsense suppressor and antisuppressor mutations at the 1409-1491 base pair in the decoding region of Escherichia coli 16S rRNA.Semantic proximity Read ↗

Alterations in ribosomal protein L19 that decrease the fidelity of translation.Semantic proximity Read ↗

Testing constraints on rRNA bases that make nonsequence-specific contacts with the codon-anticodon complex in the ribosomal A site.Semantic proximity Read ↗

Study of the functional interaction of the 900 Tetraloop of 16S ribosomal RNA with helix 24 within the bacterial ribosome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.