Article
HCF-dependent nuclear import of VP16.
The EMBO journal - 15 Jan 1999
La Boissière S, Hughes T, O'Hare P
Abstract excerpt
Transactivation by VP16 requires the formation of a multicomponent complex, the TAATGAAAT recognition factor complex (TRF.C), that contains in addition to VP16, two cellular proteins, Oct-1 and HCF. HCF binds directly to VP16 and this promotes subsequent interaction of the VP16-HCF complex with t...
Topics
- Amino Acid Sequence
- Animals
- Biological Transport, Active
- COS Cells
- Cell Compartmentation
- Cell Nucleus
- Chlorocebus aethiops
- DNA-Binding Proteins
- HeLa Cells
- Herpes Simplex Virus Protein Vmw65
- Host Cell Factor C1
- Humans
- Molecular Sequence Data
- Mutation
- Nuclear Localization Signals
- Octamer Transcription Factor-1
- Subcellular Fractions
- Transcription Factors