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Article

HCF-dependent nuclear import of VP16.

The EMBO journal - 15 Jan 1999

La Boissière S, Hughes T, O'Hare P

Abstract excerpt

Transactivation by VP16 requires the formation of a multicomponent complex, the TAATGAAAT recognition factor complex (TRF.C), that contains in addition to VP16, two cellular proteins, Oct-1 and HCF. HCF binds directly to VP16 and this promotes subsequent interaction of the VP16-HCF complex with the POU DNA-binding domain of Oct-1 and selective assembly onto target sites. Here we demonstrate a novel role of HCF in...

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Identifiers

PMID: 9889203
DOI: 10.1093/emboj/18.2.480
PMCID: PMC1171141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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