Loss of imprinting of the insulin-like growth factor II gene in renal cell carcinoma.

Article

Loss of imprinting of the insulin-like growth factor II gene in renal cell carcinoma.

Cancer research - 1 Jul 1997

Nonomura N, Nishimura K, Miki T, Kanno N, Kojima Y, Yokoyama M, Okuyama A

Abstract excerpt

Loss of imprinting (LOI) has been implicated in the pathogenesis of embryonal malignancies as well as adult cancers. Insulin-like growth factor II (IGF2) gene is an imprinted gene, normally transcribed only from the paternal allele. We investigated allele-specific expression of the IGF2 gene in 2...

Topics

Adult
Aged
Aged, 80 and over
Alleles
Blotting, Northern
Carcinoma, Renal Cell
Disease Progression
Female
Genomic Imprinting
Humans
Insulin-Like Growth Factor II
Kidney Neoplasms
Male
Middle Aged
RNA, Messenger

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