Article
Phenotypic and functional characterization of human suppressor T-cell clones: II. Activation by Mycobacterium leprae presented by HLA-DR molecules to alpha beta T-cell receptors.
Human immunology - 1 May 1990
Li S G, Elferink D G, de Vries R R
Abstract excerpt
We have been studying human T-cell clones that suppress anti-mycobacterial T-cell responses but not T-cell responses to an unrelated antigen or mitogen. In the present paper we report our studies on the activation requirements of these suppressor-T-cell clones. The suppressor-T-cell clones could proliferate and produce interferon-gamma upon stimulation with Mycobacterium leprae and other mycobacteria but not with...
Topics
- Antibodies, Monoclonal
- Antigen-Presenting Cells
- Antigens, Bacterial
- CD4 Antigens
- CD4-Positive T-Lymphocytes
- Cell Division
- Clone Cells
- Epitopes
- HLA-DR Antigens
- Humans
- Interferon-gamma