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Cell targeting and immunostimulatory properties of a novel Fcγ-receptor independent agonistic anti-CD40 antibody in rhesus macaques

2023-03-24

Abstract excerpt

Targeting CD40 by agonistic antibodies used as vaccine adjuvants or for cancer immunotherapy is a strategy to stimulate immune responses. The majority of studied agonistic anti-human CD40 antibodies require crosslinking of their Fc region to inhibitory FcγRIIb to induce immune stimulation although this has been associated with toxicity in previous studies. Here we introduce an agonistic anti-human CD40 monoclonal...

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Identifiers and source

Literature Corpus work
2ee88290-f3d1-54df-a83f-daebdde61d6c
DOI
10.1101/2023.03.22.533762
Open publication

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Cell targeting and immunostimulatory properties of a novel Fcγ-receptor independent agonistic anti-CD40 antibody in rhesus macaquesDOI 10.1101/2023.03.22.533762
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