Article
Identification of an Mhc-DPB1 allele involved in susceptibility to experimental autoimmune encephalomyelitis in rhesus macaques.
International immunology - 1 Oct 1995
Slierendregt B L, Hall M, 't Hart B, Otting N, Anholts J, Verduin W, Claas F, Jonker M, Lanchbury J S, Bontrop R E
Abstract excerpt
Experimental autoimmune encephalomyelitis (EAE) is an inducible autoimmune disorder that in rodents is known to be influenced by genetic background, specifically the Mhc class II region. Immunization of a group of outbred rhesus macaques with bovine high homogenate results in induction of the disease in approximately 65% of the animals. No clear association between the Mamu-DR or -DQ subregion of the rhesus...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Antigen Presentation
- Autoimmune Diseases
- Base Sequence
- Brain
- CD4-Positive T-Lymphocytes
- Cattle
- Disease Susceptibility
- Encephalomyelitis, Autoimmune, Experimental
- Genes, MHC Class II
- Genetic Predisposition to Disease