Article
A method for expansion of T cells from cynomolgus monkey (Macaca fascicularis).
In vitro cellular & developmental biology. Animal - 1 Sept 2018
Gao Change, Song Qian, Zhang Ming, Li Jian, Yi Miao, Dong Jian
Abstract excerpt
T cells have been successfully applied to cancer immunotherapy. However, a challenge is an expansion of T cells from cynomolgus monkey, which is a valuable non-human primate model for T cell therapy transferring to the clinic. Here, we compared several strategies to expand cynomolgus monkey T cell and developed an appropriate method. Our study demonstrated that 100 ng/ml CD3 mAb + 1% PHA+ 1000 U/ml IL2 therapy...
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