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Article

Human naive T cells activated by cytokines differentiate into a split phenotype with functional features intermediate between naive and memory T cells.

International immunology - 1 Sept 1995

Unutmaz D, Baldoni F, Abrignani S

Abstract excerpt

We have recently shown that CD45RA+CD4+ naive T cells can be activated to proliferate by a combination of IL-2, TNF-alpha and IL-6, but, at variance with TCR-mediated activation, they do not acquire the CD45RO molecule. This prompted us to investigate the phenotype of these cells and the functional features they display upon TCR stimulation. Naive T cells expanded by cytokines, though remaining CD45RA+, express a...

Topics

Adult
Cell Differentiation
Cytokines
Female
Humans
Immunologic Memory
Leukocyte Common Antigens
Lymphocyte Activation
Male
Phenotype
T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7495749
DOI: 10.1093/intimm/7.9.1417

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7495749-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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