Article

Characterisation of T cell surface phenotype and effector function in a surrogate model of rheumatoid arthritis

2009-01-01

Abstract excerpt

TNFα plays a pivotal role in the pathogenesis of rheumatoid arthritis (RA), however the mechanisms underlying its dysregulation are not completely understood. TNFα production by macrophages is dependent on their contact with synovial T cells. In an in vitro model of RA, peripheral blood lymphocytes stimulated with a cocktail of cytokines mimic this RA T cell effector function. This thesis defines and characterises...

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Literature Corpus work: ea9c07a6-f018-5a11-a2c4-ec6edda0cdb5
DOI: 10.25560/4391

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