Article
Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses.
Nature immunology - 1 Aug 2016
Pulko Vesna, Davies John S, Martinez Carmine, Lanteri Marion C, Busch Michael P, Diamond Michael S, Knox Kenneth, Bush Erin C, Sims Peter A, Sinari Shripad, Billheimer Dean, Haddad Elias K, Murray Kristy O, Wertheimer Anne M, Nikolich-Žugich Janko
Abstract excerpt
The number of naive T cells decreases and susceptibility to new microbial infections increases with age. Here we describe a previously unknown subset of phenotypically naive human CD8(+) T cells that rapidly secreted multiple cytokines in response to persistent viral antigens but differed transcriptionally from memory and effector T cells. The frequency of these CD8(+) T cells, called 'memory T cells with a naive...
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