Article
Resting CD4+ effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function.
Arthritis research & therapy - 1 Jan 2008
Brennan Fionula M, Smith Nicola M G, Owen Sally, Li Ching, Amjadi Parisa, Green Patricia, Andersson Anna, Palfreeman Andrew C, Hillyer Philippa, Foey Andrew, Beech Jonathan T, Feldmann Marc
Abstract excerpt
BACKGROUND: Previously we described a system whereby human peripheral blood T cells stimulated for 8 days in a cytokine cocktail acquired effector function for contact-dependent induction of proinflammatory cytokines from monocytes. We termed these cells cytokine-activated (Tck) cells and found that the signalling pathways elicited in the responding monocytes were identical whether they were placed in contact...
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