Article
Immunodominance among EBV-derived epitopes restricted by HLA-B27 does not correlate with epitope abundance in EBV-transformed B-lymphoblastoid cell lines.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2000
Crotzer V L, Christian R E, Brooks J M, Shabanowitz J, Settlage R E, Marto J A, White F M, Rickinson A B, Hunt D F, Engelhard V H
Abstract excerpt
Using synthetic peptides, the HLA-B27-restricted CTL response to EBV in asymptomatic virus carriers has been mapped to four epitope regions in EBV latent cycle Ags. One of these peptide-defined epitopes (RRIYDLIEL) tends to be immunodominant and is recognized in the context of all three B27 subtypes studied, B*2702, B*2704, and B*2705. The other peptide-defined epitopes induce responses only in the context of one...
Topics
- Alleles
- Antigen Presentation
- B-Lymphocytes
- Cell Line, Transformed
- Clone Cells
- Cytotoxicity, Immunologic
- Epitopes, T-Lymphocyte
- HLA-B27 Antigen
- Herpesvirus 4, Human
- Humans
- Immunodominant Epitopes
- Lymphocyte Activation