Article
The effect on cell phenotype of the mutagenic peptide of herpes simplex virus type-1.
European journal of cancer. Part B, Oral oncology - 1 Jul 1995
Das C M, Murrah V A, Zhang S, Wong G, Gilchrist E P, Shillitoe E J
Abstract excerpt
The transforming region of the genome of herpes simplex virus type-1 (HSV-1) encodes a peptide that raises the mutation frequency of cells. To find the effect of this peptide on cell phenotype, three types of cells were transfected with a shuttle vector plasmid that expressed the peptide. When im...
Topics
- Amino Acid Sequence
- Animals
- Cell Line
- Cell Transformation, Neoplastic
- Cell Transformation, Viral
- Chlorocebus aethiops
- Dexamethasone
- Herpesvirus 1, Human
- Humans
- Keratinocytes
- Mice
- Mice, Nude
- Molecular Sequence Data
- Mutation
- Peptides
- Phenotype
- Rats
- Transfection