Alterations in the cellular phenotype induced by herpes simplex viruses.

Abstract excerpt

Numerous studies have shown that herpes simplex virus types 1 and 2 (HSV-1, HSV-2) are able to transform the morphological phenotype of rodent cells. Unlike other DNA tumor viruses the transformed cells did not consistently retain or express a given set of viral genes. In fact, transformation could be obtained using fragments of viral DNA that did not wholly encode viral proteins. Of interest within the...

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