Article
Mutagenic virus replication in human tumor cells.
Cancer letters - 1 Jan 2000
Bockstahler L E, Lytle C D, Lubiniecki A S, Cantwell J M, Galleshaw J A
Abstract excerpt
Herpes simplex virus was grown in different lines of human tumor and normal cells. The progeny virus was assayed for resistance to iododeoxycytidine, an indicator of a forward mutation in the virus genome. Virus grown in cells from 4 of 5 tumor lines demonstrated greater fractions mutated to iodo...
Topics
- Animals
- Bromodeoxycytidine
- Cell Line
- Chlorocebus aethiops
- Deoxycytidine
- Drug Resistance, Microbial
- Glioma
- Humans
- Kidney
- Lung Neoplasms
- Melanoma
- Mutation
- Osteosarcoma
- Simplexvirus
- Skin
- Virus Replication