Article
Mutagenic virus replication in human tumor cells.
Cancer letters - 1 Jan 2000
Bockstahler L E, Lytle C D, Lubiniecki A S, Cantwell J M, Galleshaw J A
Abstract excerpt
Herpes simplex virus was grown in different lines of human tumor and normal cells. The progeny virus was assayed for resistance to iododeoxycytidine, an indicator of a forward mutation in the virus genome. Virus grown in cells from 4 of 5 tumor lines demonstrated greater fractions mutated to iododeoxycytidine resistance than did virus grown in 7 normal human skin cell lines. The data indicate that some lines of...
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