Article
Association of TP53 mutations with stem cell-like gene expression and survival of patients with hepatocellular carcinoma.
Gastroenterology - 1 Mar 2011
Woo Hyun Goo, Wang Xin Wei, Budhu Anuradha, Kim Yun Hee, Kwon So Mee, Tang Zhao-You, Sun Zongtang, Harris Curtis C, Thorgeirsson Snorri S
Abstract excerpt
BACKGROUND & AIMS: Mutations in TP53, a tumor suppressor gene, are associated with prognosis of many cancers. However, the prognostic values of TP53 mutation sites are not known for patients with hepatocellular carcinoma (HCC) because of heterogeneity in their geographic and etiologic backgrounds. METHODS: TP53 mutations were investigated in a total of 409 HCC patients, including Chinese (n = 336) and white (n =...
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