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Article

Control of autoantibody affinity by selection against amino acid replacements in the complementarity-determining regions.

Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 1994

Børretzen M, Randen I, Zdárský E, Førre O, Natvig J B, Thompson K M

Abstract excerpt

Rheumatoid factor (RF) autoantibodies can be produced in healthy individuals after infections or immunizations and thus escape normal tolerization mechanisms. It has not been clear whether such autoantibodies can undergo somatic hypermutation and affinity maturation similar to antibodies to exogenous antigens. We have investigated how these autoantibodies are regulated in normal individuals by analyzing the...

Topics

Antibody Affinity
Arthritis, Rheumatoid
Base Sequence
DNA Primers
Female
Genes, Immunoglobulin
Humans
Hybridomas
Immunoglobulin Heavy Chains
Immunoglobulin M

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Variable Region

Molecular Sequence Data

Mutation

Rheumatoid Factor

Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 7809146
DOI: 10.1073/pnas.91.26.12917
PMCID: PMC45551

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7809146-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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