Article
Selective breeding of rats differing in sensitivity to the effects of acute ethanol administration.
Alcoholism, clinical and experimental research - 1 Feb 1992
Draski L J, Spuhler K P, Erwin V G, Baker R C, Deitrich R A
Abstract excerpt
Selective breeding of rats for sensitivity to the anesthetic effects of ethanol is being carried out with rats derived from the genetically heterogeneous N/Nih stock. Thirteen generations of within family selection have been achieved with replicate high (HAS), low (LAS) and control alcohol sensit...
Topics
- Alcoholic Intoxication
- Aldehyde Dehydrogenase
- Animals
- Corticosterone
- Dose-Response Relationship, Drug
- Enzyme Induction
- Ethanol
- Female
- Genotype
- Male
- Metabolic Clearance Rate
- Pentobarbital
- Phenotype
- Rats
- Rats, Inbred Strains
- Selection, Genetic
- Sleep Stages