APOE is linked to Alzheimer's disease in a large pedigree.

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Article

APOE is linked to Alzheimer's disease in a large pedigree.

American journal of medical genetics - 25 Jul 1997

Cai X, Fallin D, Stanton J, Scibelli P, Duara R, Crawford F, Mullan M

Abstract excerpt

Although previous association studies have demonstrated that the APOE4 allele is a risk factor for Alzheimer's disease (AD), its value for the prediction of AD in individuals is <100%. The limited predictive value of epsilon4 is also seen in multiply affected families where the epsilon4 allele is...

Topics

Age of Onset
Aged
Alleles
Alzheimer Disease
Apolipoprotein C-I
Apolipoprotein E4
Apolipoproteins C
Apolipoproteins E
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 21
DNA
Female
Georgia
Humans
Lod Score
Male

Source

Open in PubMed

Identifiers

PMID: 9259370

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9259370-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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