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Article

APOE is linked to Alzheimer's disease in a large pedigree.

American journal of medical genetics - 25 Jul 1997

Cai X, Fallin D, Stanton J, Scibelli P, Duara R, Crawford F, Mullan M

Abstract excerpt

Although previous association studies have demonstrated that the APOE4 allele is a risk factor for Alzheimer's disease (AD), its value for the prediction of AD in individuals is <100%. The limited predictive value of epsilon4 is also seen in multiply affected families where the epsilon4 allele is not tightly linked to AD. We analyzed a large pedigree multiply affected with AD by lod score linkage analysis at the...

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Source

Identifiers

PMID: 9259370

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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