Article
Does APOE explain the linkage of Alzheimer's disease to chromosome 19q13?
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Sept 2008
Blom Elin S, Holmans Peter, Arepalli Sampath, Adighibe Omanma, Hamshere Marian L, Gatz Margaret, Pedersen Nancy L, Bergem A L Mina, Owen Michael J, Hollingworth Paul, Goate Alison, Williams Julie, Lannfelt Lars, Hardy John, Wavrant-De Vrièze Fabienne, Glaser Anna
Abstract excerpt
We have studied the impact of the apolipoprotein E gene (APOE) on the chromosome 19 linkage peak from an analysis of sib-pairs affected by Alzheimer's disease. We genotyped 417 affected sib-pairs (ASPs) collected in Sweden and Norway (SWE), the UK and the USA for 10 microsatellite markers on chromosome 19. The highest Zlr (3.28, chromosome-wide P-value 0.036) from the multipoint linkage analysis was located...
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