Detection of genotype-environment interaction in case-control studies of birth defects: how big a sample size?

Abstract excerpt

Detecting interactions between risk factors in case-control studies of birth defects and other conditions usually requires increasing the sample size beyond that needed to detect marginal effects. A special case of such interaction is genotype-environment interaction in which the effects of an exposure on disease risk are modified by genetic susceptibility. When case-control studies are designed to detect...

Topics

• Case-Control Studies
• Cleft Lip
• Cleft Palate
• Congenital Abnormalities
• Disease Susceptibility
• Environmental Exposure
• Female
• Genotype
• Humans
• Infant, Newborn
• Maternal Exposure