Article
Evaluation of two methods for assessing gene-environment interactions using data from the Danish case-control study of facial clefts.
Birth defects research. Part A, Clinical and molecular teratology - 1 Aug 2005
Etheredge Analee J, Christensen Kaare, Del Junco Deborah, Murray Jeffrey C, Mitchell Laura E
Abstract excerpt
BACKGROUND: Epidemiological investigations have begun to consider gene-environment (GE) interactions as potential risk factors for many diseases, including several different birth defects. However, traditional methodological approaches for the analysis of case-control data tend to have low power for detection of interaction effects. A log-linear approach that can impose the assumption that the genotype and...
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