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Article

Sample size requirements to detect gene-environment interactions in genome-wide association studies.

Genetic epidemiology - 1 Apr 2011

Murcray Cassandra E, Lewinger Juan Pablo, Conti David V, Thomas Duncan C, Gauderman W James

Abstract excerpt

Many complex diseases are likely to be a result of the interplay of genes and environmental exposures. The standard analysis in a genome-wide association study (GWAS) scans for main effects and ignores the potentially useful information in the available exposure data. Two recently proposed methods that exploit environmental exposure information involve a two-step analysis aimed at prioritizing the large number of...

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PMID: 21308767
DOI: 10.1002/gepi.20569
PMCID: PMC3076801

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