How much are we missing in SNP-by-SNP analyses of genome-wide association studies?

doi:10.1097/EDE.0b013e31822ffbe7

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Article

How much are we missing in SNP-by-SNP analyses of genome-wide association studies?

Epidemiology (Cambridge, Mass.) - 1 Nov 2011

Shi Min, Weinberg Clarice R

Abstract excerpt

Genome-wide association studies have discovered common genetic variants associated with susceptibility for several complex diseases, but they have been unfruitful for many others. Typically, analysis is done "agnostically," by considering one single nucleotide polymorphism (SNP) at a time and controlling the overall type I error rate by correcting for multiple testing. Such one-at-a-time analyses may be...

Topics

Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Heterozygote
Humans
Polymorphism, Single Nucleotide

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PMID: 21878815
DOI: 10.1097/EDE.0b013e31822ffbe7
PMCID: PMC4779601

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