Sample size requirements in case-only designs to detect gene-environment interaction.

doi:10.1093/oxfordjournals.aje.a009346

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Article

Sample size requirements in case-only designs to detect gene-environment interaction.

American journal of epidemiology - 1 Nov 1997

Yang Q, Khoury M J, Flanders W D

Abstract excerpt

With advances in molecular genetic technology, more studies will examine gene-environment interaction in disease etiology. If the primary purpose of the study is to estimate the effect of gene-environment interaction in disease etiology, one can do so without employing controls. The case-only des...

Topics

Case-Control Studies
Epidemiologic Methods
Genes
Genetic Markers
Genotype
Humans
Mathematics
Research Design

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