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Detecting gene-environment interactions in human birth defects: Study designs and statistical methods.

Birth defects research. Part A, Clinical and molecular teratology - 1 Aug 2015

Tai Caroline G, Graff Rebecca E, Liu Jinghua, Passarelli Michael N, Mefford Joel A, Shaw Gary M, Hoffmann Thomas J, Witte John S

Abstract excerpt

BACKGROUND: The National Birth Defects Prevention Study (NBDPS) contains a wealth of information on affected and unaffected family triads, and thus provides numerous opportunities to study gene-environment interactions (G×E) in the etiology of birth defect outcomes. Depending on the research objective, several analytic options exist to estimate G×E effects that use varying combinations of individuals drawn from...

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Identifiers

PMID: 26010994
DOI: 10.1002/bdra.23382
PMCID: PMC4537677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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