[Characterization of mutation of the P53 gene in lymphomas].

Abstract excerpt

PURPOSE: To analyze P53 mutations in a series of NHL and to determine its implication in the inactivation of the tumor suppressor function. MATERIAL AND METHODS: We analyzed 18 lymphomas by SSCP (exons 5 to 9) and subsequent sequencing technics to detect and characterize mutations on this gene. Loss of heterozigosity (LOH) was also studied with a VNTR near the p53 gene and with a intragenic microsatellite,...

Topics

• Base Sequence
• Genes, p53
• Humans
• Lymphoma, Non-Hodgkin
• Molecular Sequence Data
• Mutation
• Polymorphism, Single-Stranded Conformational