Article
A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless.
Cell - 29 May 1998
Allada R, White N E, So W V, Hall J C, Rosbash M
Abstract excerpt
We report the identification, characterization, and cloning of a novel Drosophila circadian rhythm gene, dClock. The mutant, initially called Jrk, manifests dominant effects: heterozygous flies have a period alteration and half are arrhythmic, while homozygous flies are uniformly arrhythmic. Furt...
Topics
- Animals
- Behavior, Animal
- CLOCK Proteins
- Chromosome Mapping
- Circadian Rhythm
- Cloning, Molecular
- Drosophila
- Drosophila Proteins
- Genes, Reporter
- In Situ Hybridization
- Insect Proteins
- Mammals
- Molecular Sequence Data
- Mutagenesis
- Mutation
- Nuclear Proteins
- Period Circadian Proteins
- Trans-Activators