Aberrant subcellular localization of BRCA1 in breast cancer.

doi:10.1126/science.270.5237.789

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Aberrant subcellular localization of BRCA1 in breast cancer.

Science (New York, N.Y.) - 3 Nov 1995

Chen Y, Chen C F, Riley D J, Allred D C, Chen P L, Von Hoff D, Osborne C K, Lee W H

Abstract excerpt

The BRCA1 gene product was identified as a 220-kilodalton nuclear phosphoprotein in normal cells, including breast ductal epithelial cells, and in 18 of 20 tumor cell lines derived from tissues other than breast and ovary. In 16 of 17 breast and ovarian cancer lines and 17 of 17 samples of cells obtained from malignant effusions, however, BRCA1 localized mainly in cytoplasm. Absence of BRCA1 or aberrant...

Topics

Amino Acid Sequence
BRCA1 Protein
Base Sequence
Breast
Breast Neoplasms
Cell Fractionation
Cell Line
Cell Nucleus
Cytoplasm
Female
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Neoplasm Proteins

Neoplasms

Ovarian Neoplasms

Pleural Effusion, Malignant

Source

Open in PubMed

Identifiers

PMID: 7481765
DOI: 10.1126/science.270.5237.789

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7481765-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aberrant subcellular localization of BRCA1 in breast cancer.PMID 7481765Read ↗

A nuclear function for the tumor suppressor BRCA1.Semantic proximity Read ↗

BRCA1 gene in breast cancer.Semantic proximity Read ↗

Loss of nuclear BRCA1 expression in breast cancers is associated with a highly proliferative tumor phenotype.Semantic proximity Read ↗

BRCA1 protein expression and subcellular localization in primary breast cancer: Automated digital microscopy analysis of tissue microarrays.Semantic proximity Read ↗

Differential expression and subcellular localization of murine BRCA1 and BRCA1-delta 11 isoforms in murine and human cell lines.Semantic proximity Read ↗

Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice.Semantic proximity Read ↗

Cyclin D1 protein expression and function in human breast cancerSemantic proximity Read ↗

p53-dependent BRCA1 nuclear export controls cellular susceptibility to DNA damage.Semantic proximity Read ↗

Immunohistochemical analysis of PDK1 expression in breast cancer.Semantic proximity Read ↗

Phosphatidylinositol 3-kinase/Akt signaling enhances nuclear localization and transcriptional activity of BRCA1.Semantic proximity Read ↗

Aberrant expression of TopBP1 in breast cancer.Semantic proximity Read ↗

Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.