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Article

Aberrant subcellular localization of BRCA1 in breast cancer.

Science (New York, N.Y.) - 3 Nov 1995

Chen Y, Chen C F, Riley D J, Allred D C, Chen P L, Von Hoff D, Osborne C K, Lee W H

Abstract excerpt

The BRCA1 gene product was identified as a 220-kilodalton nuclear phosphoprotein in normal cells, including breast ductal epithelial cells, and in 18 of 20 tumor cell lines derived from tissues other than breast and ovary. In 16 of 17 breast and ovarian cancer lines and 17 of 17 samples of cells obtained from malignant effusions, however, BRCA1 localized mainly in cytoplasm. Absence of BRCA1 or aberrant...

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Source

Identifiers

PMID: 7481765
DOI: 10.1126/science.270.5237.789

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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