Article
Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice.
Oncogene - 8 Nov 2001
Brodie S G, Xu X, Qiao W, Li W M, Cao L, Deng C X
Abstract excerpt
Germline mutations in the tumor suppressor gene BRCA1 predispose women to breast cancer, however somatic mutations in the gene are rarely detected in sporadic cancers. To understand this phenomenon, we examined mouse models carrying conditional disruption of Brca1 in mammary epithelium in either p53 wild type (wt) or heterozygous backgrounds. Although a p53(+/-) mutation significantly accelerated tumorigenesis,...
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