Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aberrant expression of TopBP1 in breast cancer.

Histopathology - 1 Mar 2007

Going J J, Nixon C, Dornan E S, Boner W, Donaldson M M, Morgan I M

Abstract excerpt

AIMS: The TopBP1 protein includes eight BRCT domains (originally identified in BRCA1) and has homology with BRCA1 over the carboxyl terminal half of the protein. The aim of this study was to determine whether TopBP1 is aberrantly expressed in breast cancer. METHODS AND RESULTS: Sixty-one breast carcinomas from an unselected consecutive patient cohort were studied along with 12 samples of breast tissue from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mammary Glands, Human
Share to Breast
Share to Carcinoma, Ductal, Breast

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carrier Proteins

Share to Immunohistochemistry

Share to Nuclear Proteins

Share to Rabbits

Share to Reference Values

Source

Identifiers

PMID: 17448016
DOI: 10.1111/j.1365-2559.2007.02622.x

Genes

BRCA1
TOPBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Aberrant expression of TopBP1 in breast cancer.PMID 17448016Read ↗

Regulation of p53 by TopBP1: a Potential Mechanism for p53 Inactivation in CancerSemantic proximity Read ↗

[Molecular basis of gynecological oncology--TopBP1 protein and its participation in the transcription process].Semantic proximity Read ↗

[Molecular basis of gynecological oncology - TopBP1 protein as the guardian of genome integrity].Semantic proximity Read ↗

Expression of thyroid transcription factor-1 is associated with a basal-like phenotype in breast carcinomas.Semantic proximity Read ↗

Id4 protein is highly expressed in triple-negative breast carcinomas: possible implications for BRCA1 downregulationSemantic proximity Read ↗

Increased ID4 expression, accompanied by mutant p53 accumulation and loss of BRCA1/2 proteins in triple-negative breast cancer, adversely affects survival.Semantic proximity Read ↗

A nuclear function for the tumor suppressor BRCA1.Semantic proximity Read ↗

Association between the c.*229C>T polymorphism of the topoisomerase IIβ binding protein 1 (TopBP1) gene and breast cancer.Semantic proximity Read ↗

Aberrant subcellular localization of BRCA1 in breast cancer.Semantic proximity Read ↗

FRA-1 protein overexpression is a feature of hyperplastic and neoplastic breast disordersSemantic proximity Read ↗

NBS1 binds directly to TOPBP1 via disparate interactions between the NBS1 BRCT1 domain and the TOPBP1 BRCT1 and BRCT2 domainsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.