Article
p53-dependent BRCA1 nuclear export controls cellular susceptibility to DNA damage.
Cancer research - 15 Aug 2011
Jiang Juhong, Yang Eddy S, Jiang Guochun, Nowsheen Somaira, Wang Hong, Wang Tong, Wang Yihan, Billheimer Dean, Chakravarthy A Bapsi, Brown Melissa, Haffty Bruce, Xia Fen
Abstract excerpt
Subcellular localization regulates BRCA1 function, and BRCA1 is exported to the cytoplasm following DNA damage in a p53-dependent manner. Because more than 50% of solid tumors harbor p53 mutations, it is possible that genetically wild-type (wt) BRCA1 is functionally abnormal through compromised nuclear-cytoplasmic shuttling in sporadic breast cancer patients with dysfunctional p53. In this study, we have...
Topics
- BRCA1 Protein
- Cell Line, Tumor
- DNA Damage
- Humans
- Mutation
- Protein Transport
- Subcellular Fractions
- Transcription, Genetic
- Tumor Suppressor Protein p53