Article
Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation.
Nature communications - 22 Apr 2022
He Zhengcheng, Ghorayeb Ryan, Tan Susanna, Chen Ke, Lorentzian Amanda C, Bottyan Jack, Aalam Syed Mohammed Musheer, Pujana Miguel Angel, Lange Philipp F, Kannan Nagarajan, Eaves Connie J, Maxwell Christopher A
Abstract excerpt
Preneoplastic mammary tissues from human female BRCA1 mutation carriers, or Brca1-mutant mice, display unexplained abnormalities in luminal differentiation. We now study the division characteristics of human mammary cells purified from female BRCA1 mutation carriers or non-carrier donors. We show primary BRCA1 mutant/+ cells exhibit defective BRCA1 localization, high radiosensitivity and an accelerated entry into...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.