Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Termination and peptide release at the upstream open reading frame are required for downstream translation on synthetic shunt-competent mRNA leaders.

Molecular and cellular biology - 1 Sept 2000

Hemmings-Mieszczak M, Hohn T, Preiss T

Abstract excerpt

We have shown recently that a stable hairpin preceded by a short upstream open reading frame (uORF) promotes nonlinear ribosome migration or ribosome shunt on a synthetic mRNA leader (M. Hemmings-Mieszczak and T. Hohn, RNA 5:1149-1157, 1999). We have now used the model mRNA leader to study further the mechanism of shunting in vivo and in vitro. We show that a full cycle of translation of the uORF, including...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Untranslated Regions
Share to Cell-Free System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Centrifugation, Density Gradient

Share to Chloramphenicol O-Acetyltransferase

Share to Open Reading Frames

Share to Protein Biosynthesis

Share to Protoplasts

Share to Ribosomes

Source

Open in PubMed Open full text

Identifiers

PMID: 10938098
DOI: 10.1128/MCB.20.17.6212-6223.2000
PMCID: PMC86096

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Termination and peptide release at the upstream open reading frame are required for downstream translation on synthetic shunt-competent mRNA leaders.PMID 10938098Read ↗

Identification of a cis-acting element required for shunt-mediated translational initiation of the Sendai virus Y proteins.Semantic proximity Read ↗

Cross-species functionality of pararetroviral elements driving ribosome shunting.Semantic proximity Read ↗

Sequences 5' of the first upstream open reading frame in GCN4 mRNA are required for efficient translational reinitiation.Semantic proximity Read ↗

Translation of cIAP2 mRNA Is Mediated Exclusively by a Stress-Modulated Ribosome ShuntSemantic proximity Read ↗

Feedback from the Nascent Chain Triggers Ribosomal Frameshifting and Transcript DecaySemantic proximity Read ↗

Translation initiation mediated by RNA loopingSemantic proximity Read ↗

Flexibility and modulation of translation initiation in enterovirus genomesSemantic proximity Read ↗

RNA stem-loop enhanced expression of previously non-expressible genes.Semantic proximity Read ↗

Upstream translation initiation expands the coding capacity of segmented negative-strand RNA virusesSemantic proximity Read ↗

Transcriptome-wide investigation of stop codon readthrough in <i>Saccharomyces cerevisiae</i>Semantic proximity Read ↗

Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in S. cerevisiae.Semantic proximity Read ↗

The h subunit of eIF3 promotes reinitiation competence during translation of mRNAs harboring upstream open reading frames.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.