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Article

The h subunit of eIF3 promotes reinitiation competence during translation of mRNAs harboring upstream open reading frames.

RNA (New York, N.Y.) - 1 Apr 2010

Roy Bijoyita, Vaughn Justin N, Kim Byung-Hoon, Zhou Fujun, Gilchrist Michael A, Von Arnim Albrecht G

Abstract excerpt

Upstream open reading frames (uORFs) are protein coding elements in the 5' leader of messenger RNAs. uORFs generally inhibit translation of the main ORF because ribosomes that perform translation elongation suffer either permanent or conditional loss of reinitiation competence. After conditional loss, reinitiation competence may be regained by, at the minimum, reacquisition of a fresh methionyl-tRNA. The...

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Share to 5' Untranslated Regions
Share to Basic-Leucine Zipper Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20179149
DOI: 10.1261/rna.2056010
PMCID: PMC2844622

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