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Article

Clinical significance of FAK expression in human neoplasia.

1 May 2008

Abstract excerpt

Focal Adhesion Kinase is a 119-121 kDa nonreceptor protein kinase widely expressed in various tissues and cell types. Several studies showed that FAK plays an important role in integrin signaling. Once activated by integrin and non-integrin stimuli, it binds and activates several other molecules, such as Src, p130Cas, Grb2, PI3K and paxillin, thus promoting signaling transduction. In normal cells FAK activity is...

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PMID: 18283648
DOI: 10.14670/hh-23.629

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