Article
Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development.
Genes & development - 1 Oct 1999
Woldeyesus M T, Britsch S, Riethmacher D, Xu L, Sonnenberg-Riethmacher E, Abou-Rebyeh F, Harvey R, Caroni P, Birchmeier C
Abstract excerpt
The ErbB2 tyrosine kinase functions as coreceptor for the neuregulin receptors ErbB3 and ErbB4 and can participate in signaling of EGF receptor (ErbB1), interleukin receptor gp130, and G-protein coupled receptors. ErbB2(-/-) mice die at midgestation because of heart malformation. Here, we report a genetic rescue of their heart development by myocardial expression of erbB2 cDNA that allows survival of the mutants...
Topics
- Alleles
- Animals
- Heart
- Homeobox Protein Nkx-2.5
- Homeodomain Proteins
- Mice
- Mice, Mutant Strains
- Motor Neurons
- Mutation
- Neural Crest
- Neuromuscular Junction
- Peripheral Nervous System
- Receptor, ErbB-2
- Schwann Cells