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Article

STAT5b is a key effector of NRG-1/ERBB4-mediated cardiomyocyte growth

2022-10-06

Abstract excerpt

The growth factor neuregulin-1 (NRG-1) regulates hypertrophic and hyperplastic myocardial growth and is currently under clinical investigation as a treatment for heart failure. We have previously demonstrated that an isoform of the NRG-1 receptor ERBB4 (ERBB4 JM-b) expressed in cardiomyocytes selectively regulates the activation of STAT5b. To explore the role of STAT5b in NRG-1/EBBB4 mediated cardiomyocyte growth,...

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Literature Corpus work
b21d4c49-e7c3-5919-9df3-5b07400d6f99
DOI
10.1101/2022.10.05.510958
Open publication

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STAT5b is a key effector of NRG-1/ERBB4-mediated cardiomyocyte growthDOI 10.1101/2022.10.05.510958
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