Linkage of high-affinity IgE receptor gene with bronchial hyperreactivity, even in absence of atopy.

doi:10.1016/s0140-6736(95)91863-9

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Article

Linkage of high-affinity IgE receptor gene with bronchial hyperreactivity, even in absence of atopy.

Lancet (London, England) - 11 Nov 1995

van Herwerden L, Harrap S B, Wong Z Y, Abramson M J, Kutin J J, Forbes A B, Raven J, Lanigan A, Walters E H

Abstract excerpt

Asthma is a manifestation of bronchial hyperreactivity (BHR) and forms part of the spectrum of atopic disease. Some pedigree studies of atopy have suggested linkage with the high-affinity IgE receptor (Fc epsilon RI beta) gene on chromosome 11q13, but others find no linkage. The molecular genetics of asthma and BHR have not been studied in the general population. We examined the genetic linkage of the Fc epsilon...

Topics

Adult
Alleles
Asthma
Bronchial Hyperreactivity
Bronchoconstrictor Agents
Chromosome Mapping
Chromosomes, Human, Pair 11
Female
Genes, Immunoglobulin
Genetic Linkage
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Hypersensitivity

Introns

Male

Methacholine Chloride

Microsatellite Repeats

Middle Aged

Source

Open in PubMed

Identifiers

PMID: 7475718
DOI: 10.1016/s0140-6736(95)91863-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7475718-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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